EP243 - Characteristics of ocular involvement in Behçet disease in Egyptian patients.




To determine characteristics of ocular involvement in Behçet disease in Egyptian patients.


Retrospective review of 44 patients who met the revised International Criteria for BD and presented over the past 2 years to the Ophthalmology Department at Alexandria Main university Hospital.


81 eyes of 44 patients were included. 79.5% were male. Mean age at presentation was 37.70 ± 9.63 years. Mean duration of disease was 76.0 ± 52.76 months. Oral ulcer was described in 100% of patients. Systemic manifestations included genital ulcers 65.9%, pseudofolliculitis 31.8%, arthritis 22.7%,erythema nodosum 20.5% and venous thrombosis 6.8% .Ocular involvement was bilateral in 84.1% of patients . Panuveitis was the most common presentation 45.4% followed by posterior uveitis and retinal vasculitis .Isolated anterior uveitis was detected in 20.4% of patients. 81.8% of patients were treated with systemic corticosteroids with Immunomodulatory Therapy(IMT).Azathioprine was the most used IMT in 50% of patients ,followed by cyclosporine.7 patients received biologics after failure of other treatments. Posterior synechiae was the most common complication 40.9% followed by cataract 31.8% which was associated with prolonged duration of disease (p=0.032), glaucoma 18.2% and RD 4.5%. 6 patients had Phthisis bulbi in one eye at presentation.SD-OCT macular changes in 37 eyes showed ERM in 57.6% of eyes, macular edema in 39.4% , ellipsoid zone damage in 45.5% , and foveal atrophy in 33.3% .One eye had full thickness macular hole.


In Egyptian patients ocular BD typically arises in the third decade, is more common in males, and predominantly manifests as a bilateral panuveitis. Prolonged duration of disease is associated with ocular complications, structural macular damage and loss of useful vision.

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