EP242 - Etiology of uveitis in a tertiary center in Norway

EIDET Jon Roger

ERICHSEN Anne Kjersti

SØRLAND Ragnhild

JONSDOTTIR Thora

BROMNES Marius

Purpose

To explore the causes of uveitis in patients referred to the Department of Ophthalmology at Oslo University Hospital (OUH) in Norway.

Methods

All adult uveitis patients referred for a uveitis work-up at OUH during 2020 and 2021 were consecutively included. The study was performed according to the guidelines of the Declaration of Helsinki.

Results

One hundred fifty-eight uveitis patients were identified, encompassing 93 women and 65 men. The mean age was 48.3 ± 19.2 years. The majority of the patients were Caucasians (83.5%), while Africans (7.6%), Asians (7.6%), and South Americans (1.3%) represented minorities. The uveitis type was most commonly anterior (45.6%) and less commonly posterior (21.5%) or intermediary (17.7%). Scleritis (9.5%) and pan-uveitis (5.7%) were the least common. Most uveitis cases were defined as autoimmune (85.4%), while 12.7% were due to infectious agents, and 1.9% were neoplastic. The autoimmune subgroups were idiopathic (42.4%), HLA-B27 and/or Bechterew’s disease (14.6%), sarcoidosis (6.3%), JIA (3.8%), Behcet’s disease (3.2%), Birdshot chorioretinopathy (2.5%), TINU (1.9%), PIC (1.9%), multiple sclerosis (1.9%), APMPPE (1.3%), Fuchs’ uveitis syndrome (1.3%), inflammatory bowel disease (1.3%), retinal vasculitis (1.3%), MEWDS (0.6%), multifocal choroiditis (0.6%), and rheumatoid arthritis (0.6%). The infectious subgroups were toxoplasmosis (6.3%), presumed ocular tuberculosis (3.2%), cytomegalovirus (1.3%), varicella-zoster virus (1.3%), and herpes simplex virus (0.6%). All 1.9% of neoplastic cases were due to ocular lymphoma.

Conclusions

The majority of uveitis cases at a tertiary center in Norway's most significant health region represent autoimmune diseases, of which HLA-B27 and sarcoidosis are the most commonly identified causes.




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