Purpose

To describe the design, purpose, and application of a new international multicenter clinical registry for ocular inflammation.

Methods

The OASIS Clinical Registry was designed as a primarily web-based platform (https://oasis.infectiousuveitis.org/) with alternative offline modes of access. Built with end-users in mind, the platform is user-friendly, easily accessible, and contains in-built smart features to simplify use. As patient data is collected, extensive data security measures are included. A comprehensive set of clinical data ranging from demographics, past medical history, clinical presentation, working diagnosis to visual outcomes are collected over a range of time points. Additionally, clinical images may be uploaded. Data can be entered either retrospectively or prospectively

Results

We have developed a comprehensive centralized data repository that has a wide variety of applications. The registry may be utilized as a tool for epidemiological analysis and monitoring of side effects and the safety efficacy of treatments. Furthermore, the registry may also be utilized as a platform for the development of new classification and diagnostic systems, as well as treatment and prognostication guidelines and tools for uveitis.

Conclusions

The OASIS clinical registry, involving international multicenter data and images, has the potential to facilitate further advancements in the diagnosis, management, and prognostication of ocular inflammatory conditions through the provision of novel research opportunities. This novel clinical practice protocol integrating a strong research component in it can be a prototype protocol for similar other clinical registries, particularly for rarer diseases.